Postoperative Delirium
Conditions
Interventions
EA group:Electroacupuncture stimulation at bilateral Neiguan (PC6) and Shenmen (HT7) points
Sham EA group:Sham acupuncture stimulation at sham PC6 and sham HT7 points
Sponsors
Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University)
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 65 - 90 years old; 2. ASA grade I - III; 3. Scheduled for non-cranial 3-4 grade surgeries; 4. Mini-Mental State Examination (MMSE) score < 24 (combined with cognitive impairment, refer to CIRCULATION. 2024; 150(4): 272-282.); 5. The patient or their family can provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Damage or infection of the skin at the acupuncture intervention site; 2. Coagulation dysfunction or bleeding disorders; 3. Communication disorders; 4. Terminal stage with concurrent malignant tumors, severe organ failure, etc.; 5. Patients with dementia and severe mental disorders; 6. BMI >= 30; 7. History of drug abuse; 8. Use of drugs that may affect peripheral B cells and neurotransmitter levels; 9. Undergoing anti-bacterial/viral treatment; 10. Acute or currently infected; 11. Systemic inflammatory diseases; 12. Hypersensitive state; 13. Hematological tumors; 14. Immune deficiency diseases such as HIV, etc.; 15. Use of immunosuppressive or cytotoxic drugs; 16. Autonomic nervous system disorders or diseases; 17. Decompensated cardiovascular and cerebrovascular diseases; 18. Blood transfusion during surgery; 19. Surgery duration less than 2 hours; 20. Missing data; 21. Postoperative admission to ICU; 22. Patients who refuse cooperation and request to withdraw.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium (POD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of postoperative delirium;Heart rate variability parameters;Peripheral blood biomarkers of different autonomic nervous system activities;Functional changes in peripheral blood B lymphocytes;Levels and apoptosis of peripheral blood B lymphocytes and their subsets; | — |
Countries
China
Contacts
Public ContactSiyou Tan
Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University)
Outcome results
None listed