Hematologic malignancies
Conditions
Interventions
Group A:oliceridine fumarate was slowly injected intravenously according to the modified sequential method, and ciprofol 0.5 mg/kg was slowly injected intravenously over
Sponsors
Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
8 Years to 16 Years
Inclusion criteria
Inclusion criteria: 1.Children aged between 8 and 16 years old who require lumbar puncture due to clear clinical diagnosis; 2. The American Society of Anesthesiologists (ASA) classification is I-III, indicating that the child's physical condition can tolerate lumbar puncture procedures and related drug interventions; 3. The guardian of the patient fully understands the purpose, methods, potential risks, and expected benefits of this study, and voluntarily signs an informed consent form to ensure that the study is conducted in accordance with ethical standards.
Exclusion criteria
Exclusion criteria: 1. Children with a clear history of allergies tooliceridine fumarate or similar drugs should avoid severe allergic reactions; 2. Children with severe liver and kidney dysfunction, as abnormal liver and kidney function may affect the metabolism and excretion of drugs, thereby increasing the risk of adverse drug reactions; 3. Children with neurological disorders that may interfere with the accuracy of motor judgment, such as severe cerebral palsy, status epilepticus, etc., should ensure the reliability of the primary outcome measures; 4. For children who have recently (within one week) used other potent analgesics or drugs that affect neurological function, prevent drug interactions from interfering with research results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Movement response; | — |
Secondary
| Measure | Time frame |
|---|---|
| Numerical Rating Scale point;Modified Observer's Assessment of Alertness and Sedation; | — |
Countries
China
Contacts
Public ContactYun'an Song
Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University
Outcome results
None listed