Cognitive Dysfunction
Conditions
Interventions
Nalbuphine Group:Nalbuphine 0.2 mg/kg intravenous injection at anesthesia induction
maintenance: Dexmedetomidine 0.3-0.5 µg/kg/h, propofol plasma target-controlled infusion (TCI) 1.8-3.0 µg/ml, remifentanil 0.1-0.2 µg/kg/min
postoperative analgesia with sufentanil PCA (background infusion 2 ml/h) and rescue analgesia (ketorolac tromethamine 30 mg or tramadol 1 mg/kg).
Conventional Anesthesia Group (Placebo Group):Anesthesia induction: Midazolam 0.05 mg/kg, dexmedetomidine loading dose 0.5 µg/kg, propofol plasma target-controlled infusion (TCI) 2.5-4 µg/ml, rocuroni
maintenance: dexmedetomidine 0.3-0.5 µg/kg/h, propofol plasma TCI 1.8-3.0 µg/ml, remifentanil 0.1-0.2 µg/kg/min
postoperative analgesia regimen same as nalbuphine group (sufentanil PCA and rescue analgesia).
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Select patients scheduled for thoracoscopic surgery under general anesthesia in our hospital (with the surgical type being segmental or lobectomy of the lung); 2. Aged 50 to 70; 3. The BMI is 19-25kg/m^2; 4. ASA Grade ?-?; 5. Be able to communicate normally and cooperate in various scoring processes. 6. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of thoracic surgery; 2. scheduled for repeat surgery at the ipsilateral site during the study period; 3. uncontrolled hypertension, coronary heart disease, or hepatic/renal dysfunction; 4. uncontrolled hyperthyroidism; 5. visual impairment; 6. known allergy to the study drugs; 7. psychiatric disorders; 8. severe cardiopulmonary dysfunction; 9. a history of chronic pain or long-term use of opioids or psychotropic drugs; 10. claustrophobia; 11. a history of cerebrovascular accident; 12. or inability to comprehend or utilize the pain scoring system.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Cognitive Function at 48 Hours;Resting-State fMRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Scores for Depression and Anxiety;Pulmonary Complications;Inflammatory Cytokines IL-1 and IL-6;Confusion Assessment Method (CAM) score;Visual Analogue Scale (VAS) score for pain; | — |
Countries
China
Contacts
Public ContactFan Qisen
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed