Postoperative negative behaviors
Conditions
Interventions
Esketamine Group (EKM Group):Esketamine 0.3 mg/kg intravenously administered 15 minutes before the end of surgery
Saline Group (SAL Group):Normal saline 0.1 ml/kg intravenously administered 15 minutes before the end of surgery
Sponsors
Zhongshan Ophthalmic Center, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
6 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1:elective ophthalmic surgery under general anesthesia with an estimated operative time not exceeding 2 hours; 2:age 6–12 years; 3: American Society of Anesthesiologists (ASA) physical status I–II; 4: agreement to participate in the trial and voluntary signed informed consent.
Exclusion criteria
Exclusion criteria: 1:Allergy or contraindication to esketamine or any of its components; 2:Upper respiratory tract infection within the past 14 days; 3: Premature birth, or history of congenital, genetic, psychiatric diseases, or epilepsy; 4:Presence of intellectual disability or cognitive dysfunction before surgery; 5: Congenital heart disease, abnormal liver or kidney function, glaucoma, or elevated intraocular pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of emergence delirium during the anesthesia recovery period.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Post Hospitalization Behavior Questionnaire for Ambulatory Surgery (PHBQ-AS) score;Children's Sleep Habits Questionnaire (CSHQ) score;PAED scores at different time points during the anesthesia recovery period.;Incidence of postoperative complications in the PACU and within 24 hours postoperatively; | — |
Countries
China
Contacts
Public ContactGan Xiaoliang
Zhongshan Ophthalmic Center, Sun Yat-sen University
Outcome results
None listed