Thyroid nodules and thyroid cancer
Conditions
Interventions
Control Group (Group B):Intravenous Injection of Morphine Hydrochloride Injection
Experimental Group (Group A):Intravenous Injection of Hydromorphone Hydrochloride Injection
Sponsors
Bejing Tongren Hospital, Capital Medical Uniersity
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Voluntarily participate and sign the informed consent form in writing; 2.Aged 18 to 80, with no restriction on gender; 3.Patients scheduled for elective ablation surgery for thyroid nodules and thyroid cancer; 4.Eastern Cooperative Oncology Group (ECOG) Performance Status Score <= 2;
Exclusion criteria
Exclusion criteria: 1.Patients with severe coagulation disorders that cannot be corrected; 2.Patients with acute or severe bronchial asthma; 3.Patients with respiratory depression symptoms who lack cardiopulmonary resuscitation (CPR) equipment or monitoring devices; 4.Patients at risk of gastrointestinal obstruction, especially those with paralytic ileus; 5.Patients allergic to opioid drugs / patients with opioid addiction; 6.Abnormal laboratory results with significant clinical significance, such as serum creatinine = 2 times the upper limit of normal (ULN), alanine transaminase (ALT) or aspartate transaminase (AST) = 2.5 times the ULN, or Child-Pugh Class C liver function; 7.Patients with cognitive impairment; 8.Patients who used other analgesic drugs within 3 days before surgery; 9.Investigators directly involved in the trial or their family members; 10.Patients who participated in other clinical trials within the previous 30 days; 11.Other diseases and conditions that are considered ineligible for enrollment by the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximum Intraoperative Pain Score;Incidence of Adverse Reactions; | — |
Secondary
| Measure | Time frame |
|---|---|
| During the treatment period, monitor the patient's vital signs such as heart rate, blood pressure, blood oxygen saturation, and respiratory rate.;Duration of Surgery (min);Analgesic Drug Dosage (mg);Patient Satisfaction Assessment;NRS Scores at Each Measurement Time Point;Postoperative Recovery Quality Assessment (QoR-15);Concomitant Medications? / Rescue Medication Status / Rescue Medication Usage;Willingness to receive interventional treatment again after discharge; | — |
Countries
China
Contacts
Public ContactWei Li
Bejing Tongren Hospital, Capital Medical Uniersity
Outcome results
None listed