Postoperative thrombophilia after cardiac valve surgery
Conditions
Interventions
The moderate-to-low thrombotic-risk non-bridging group:Anticoagulation with warfarin
The moderate-to-low thrombotic-risk bridging group:Anticoagulation with warfarin bridged by low-molecular-weight heparin
The high thrombotic-risk non-bridging group:Anticoagulation with warfarin
The high thrombotic-risk bridging group:Anticoagulation with warfarin bridged by low-molecular-weight heparin
Sponsors
Hainan General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients undergoing cardiac valve replacement surgery in the Department of Cardiac Surgery, Hainan General Hospital.
Exclusion criteria
Exclusion criteria: 1. Patients with renal failure (serum creatinine > 150 µmol/L); 2. Pregnant women; 3. Patients receiving LMWH for less than 2 days postoperatively; 4. Patients with other hematological diseases; 5. Patients with poor compliance, unable to adhere to follow-up visits or scheduled blood sampling during hospitalization; 6. Participants in other drug trials; 7. Patients with contraindications to warfarin or low-molecular-weight heparin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anti-FXa level;Antithrombin activity;International Normalized Ratio;Thrombotic events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bleeding events; | — |
Countries
China
Contacts
Public ContactDanna Wu
Hainan General Hospital
Outcome results
None listed