Comparison of the Incidence of Hypotension after Anesthesia Induction Between Ciprofol and Propofol in Elderly Patients: A Single-Center, Randomized, Controlled, Crossover Study

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600123593

Enrollment

Unknown

Registered

2026-04-28

Start date

2026-05-05

Completion date

Unknown

Last updated

2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Older patients with glaucoma require two surgeries under general anesthesia

Interventions

Case Group:Induction and maintenance of propofol anaesthesia Induction and maintenance of cyclopropane anaesthesia The two anaesthetic regimens were administered in a randomised crossover design

Eligibility

Sex/Gender

All

Age

65 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1.Patients scheduled to undergo two elective ophthalmic surgeries (e.g., for glaucoma or cataract) under general anesthesia at the Eye & ENT Hospital of Fudan University between May 2026 and May 2027, with the second surgery planned within 1 week to 1 month (inclusive) after the first, and meeting the following criteria:; 1. aged 65–90 years; 2. ASA physical status II–III; 3. having provided signed informed consent;

Exclusion criteria

Exclusion criteria: 1. patients with ASA physical status IV; 2. BMI >= 30 kg/m²; 3. known allergy to lipid emulsions such as ciprofol or propofol; 4. severe cognitive impairment or history of delirium; 5. severe hepatic dysfunction; 6. renal impairment requiring dialysis; 7. cardiac function grade 3 or higher; 8. untreated or unstable ischemic heart disease; 9. severe valvular disease; 10. second-degree or higher atrioventricular block; 11. mean arterial pressure (MAP) <60 mmHg before anesthesia induction; 12. actual or anticipated difficult airway management;

Design outcomes

Primary

Measure	Time frame
The incidence of hypotension within 10 minutes after the initiation of anesthesia induction.;	—

Secondary

Measure	Time frame
Types of medications and frequency of treatment for hypotension;Dosage of cyclopofol/propofol for anesthesia induction;Discharge time from the PACU;Time from anesthesia induction start to loss of consciousness;Percentage of time that BIS values are between 40 and 60;Postoperative adverse events;	—

Countries

China

Contacts

Public ContactHan Yuan

Eye & ENT hospital of Fudan University

yuan.han@fdeent.org+86 13852470693

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026