Drug-induced liver injury, DILI
Conditions
Interventions
Observation Group:None
Sponsors
Fifth Medical Center, Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with clinical diagnosis who meet the diagnostic criteria or medical records of drug-induced liver injury: "drug-induced liver injury" or "drug-induced liver disease" or "drug-induced hepatitis" or "drug-induced liver injury" or "drug-induced cirrhosis (compensated period)" or other terms diagnosed as drug-induced liver injury; 2. Age range of subjects: >=18 years old; 3. RUCAM score >= 6 points; 4. Patients voluntarily participated and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Age under 18 years; 2. Patients with liver injury not caused by drugs; 3. Current liver biochemical abnormalities caused by other etiologies (e.g., viral hepatitis, alcoholic liver disease, metabolic dysfunction-associated fatty liver disease, autoimmune liver disease, etc.); 4. Severe or life-threatening diseases of the heart, lungs, brain, kidneys, gastrointestinal tract, or systemic conditions; 5. Patients unable to express their chief complaints, such as those with mental disorders; 6. Patients with poor compliance who are unable to cooperate; 7. Pregnant or lactating women; 8. Participation in other clinical trials within the past 3 months; 9. Any other conditions deemed inappropriate for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relationship between different treatment regimens and prognosis of DILI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence rate of chronicity in DILI;Rate of severe progression in DILI;Risk factors for chronic course development in DILI;Risk factors for severe progression in DILI;Cost-effectiveness ratio of different treatment regimens in DILI patients;Impact of traditional Chinese medicine constitution classification on chronicity/severe progression in DILI;Effect of different treatment regimens on TCM constitution scores in DILI patients;Relapse rate after recovery from DILI;Changes in clinical laboratory indicators (e.g., ALT, AST); | — |
Countries
China
Contacts
Public ContactLu Yinying
Fifth Medical Center, Chinese PLA General Hospital
Outcome results
None listed