Female infertility (advanced age)
Conditions
Interventions
LAH group:Laser-assisted hatching
Non-LAH group:No laser-assisted hatching
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
Female
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Female age >= 35 years; 2.First or second vitrified-warmed embryo transfer cycle; 3.Quality of embryos for transfer meeting the criteria: Grade I, II, CP or above (cleavage-stage embryos); Grade 4BC/CB or above (blastocysts); 4.Provide written informed consent;
Exclusion criteria
Exclusion criteria: 1.Use of donor oocytes or sperm, or planned preimplantation genetic testing (PGT); 2.Severe immune or chromosomal abnormalities; 3.Uterine cavity abnormalities (i.e., adenomyosis, submucous uterine fibroids, hydrosalpinx, uterine septum, and endometrial polyps); 4.Embryos with an abnormal zona pellucida; 5.Complicated with severe underlying diseases (e.g., uncontrolled hypertension/diabetes mellitus, active malignant tumors); 6.A history of recurrent implantation failure (>=2 cycles) or recurrent miscarriage (>=2 episodes);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy rate;Biochemical pregnancy rate;Ectopic pregnancy rate;Neonatal complication rate;Macrosomia rate;Low birth weight rate;Miscarriage rate;Clinical pregnancy rate;Preterm birth rate;Implantation rate;Congenital malformation rate;Multiple pregnancy rate; | — |
Countries
China
Contacts
Public ContactJiang Shutian
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed