Pediatric osteomyelitis
Conditions
Interventions
Suspected osteomyelitis cases:None
Confirmed cases of osteomyelitis in children and a considerable number of control groups:None
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Age: Children and adolescents aged from 1 month to 18 years. 2. Clinically Suspected Acute Osteomyelitis: Meeting at least two of the following criteria: (1) Local bone pain, tenderness, or limited movement; (2) Fever > 38.5°C; (3) Serum C-reactive protein (CRP) > 20 mg/L or erythrocyte sedimentation rate (ESR) > 20 mm/h. 3. Imaging Evaluation: Underwent ultrasound examination of the affected bone during the diagnostic and treatment process. 4. Definite Final Diagnosis: Patients were categorized into a "confirmed group" and a "control (non-osteomyelitis) group" based on the final clinical diagnosis (gold standard). Gold Standard Definition: (1) Confirmed Group: Diagnosis of acute osteomyelitis confirmed by MRI and/or pus culture from surgery/aspiration, or confirmed by complete clinical and radiological recovery following standard antibiotic treatment; (2) Control Group: Children with initial suspicion but ultimately ruled out for osteomyelitis, diagnosed with conditions such as cellulitis, septic arthritis, trauma, or bone tumors, and confirmed by subsequent follow-up (of at least 1 month).
Exclusion criteria
Exclusion criteria: 1. Chronic osteomyelitis (symptom duration >= 3 months), post-traumatic or postoperative osteomyelitis. 2. Presence of other active severe infections (such as septic shock), immunodeficiency diseases, malignant tumors, or autoimmune diseases. 3. Missing or incomplete key clinical, laboratory, or imaging data. 4. Poor quality ultrasound images in retrospective cases, making re-analysis and scoring impossible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity;Positive Predictive Value;Negative Predictive Value;Positive Likelihood Ratio;Negative Likelihood Ratio;Area Under the Receiver Operating Characteristic Curve;Calibration (Calibration Curve, Hosmer-Lemeshow Test);Clinical Utility (Decision Curve Analysis); | — |
Countries
China
Contacts
Public ContactLu Hongxu, Tang Xiaoli
Children's Hospital of Chongqing Medical University
Outcome results
None listed