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Effect of Permissive Hypercapnia on Emergence Time in Patients Undergoing Ambulatory Hysteroscopy Surgery

Effect of Permissive Hypercapnia on Emergence Time in Patients Undergoing Ambulatory Hysteroscopy Surgery

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600123553
Enrollment
Unknown
Registered
2026-04-27
Start date
2026-05-01
Completion date
Unknown
Last updated
2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emergence from anesthesia

Interventions

Permissive Hypercapnia Group:Adjust tidal volume and respiratory rate to achieve and maintain ETCO2 levels between 50 and 55 mmHg.
Normocapnia Group:Adjust tidal volume and respiratory rate to achieve and maintain ETCO2 levels between 35 and 40 mmHg.

Sponsors

Obstetrics & Gynecology Hospital of Fudan University, Yangtze River Delta Integration Demonstration Zone (QingPu)
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Female patients aged 18 to 65 years; 2. American Society of Anesthesiologists (ASA) physical status I to II; 3. Scheduled for hysteroscopic surgery under general anesthesia with laryngeal mask airway (LMA) and total intravenous anesthesia (TIVA); 4. Able to comprehend and complete the Quality of Recovery-15 (QoR-15) questionnaire; 5. All patients voluntarily participate in this study and have signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Presence of psychiatric, respiratory, hepatic, renal, or neurological diseases that are under treatment; 2. Use of sedatives or other medications that may interfere with the study; 3. Alcohol dependence; 4. Breastfeeding women; 5. Known allergy to any of the medications used in the study protocol; 6. Body Mass Index (BMI) >= 30 kg/m^2.

Design outcomes

Primary

MeasureTime frame
Time to emergence from anesthesia;

Secondary

MeasureTime frame
Quality of postoperative recovery;Perioperative vital signs and depth of anesthesia;Length of stay in the post-anesthesia care unit (PACU);Time to return of spontaneous breathing;Time to spontaneous eye opening;

Countries

China

Contacts

Public ContactChen Xiangde

Obstetrics & Gynecology Hospital of Fudan University, Yangtze River Delta Integration Demonstration Zone (QingPu)

cxd6342@163.com+86 159 0068 9269

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026