Neurotrophic Keratitis
Conditions
Interventions
NK group:NA
Sponsors
Eye Hospital, Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Healthy group: (1) Age >=18 years, able to fully understand the study instructions and cooperate in completing all subjective examination items; (2) After fully understanding the purpose, methods, potential benefits and risks of this study, voluntarily participate in the study, and personally sign the written informed consent form, with good compliance and cooperation with follow-up visits. (3) Confirmed by slit-lamp microscope examination that both eyes have no active ocular surface disease, and no clinical evidence of corneal hypoesthesia. 2.Neurotrophic keratitis patient group: (1) Age >=18 years, able to fully understand the study instructions and cooperate in completing all subjective examination items; (2) After fully understanding the purpose, methods, potential benefits and risks of this study, voluntarily participate in the study, and personally sign the written informed consent form, with good compliance and cooperation with follow-up visits; (3) Based on medical history, signs and auxiliary examination results, clinically diagnosed as neurotrophic keratitis with reference to the "Chinese Expert Consensus on the Diagnosis and Treatment of Neurotrophic Keratitis (2021)"; all patients must be clearly diagnosed as "neurotrophic keratitis" by a specialist in the Corneal and Ocular Surface Disease Department of the Eye Hospital of Wenzhou Medical University in the outpatient clinic. (4) Able to tolerate the airflow stimulation and mechanical stimulation during the examination process, i.e., not in the acute phase, and no risk of corneal perforation. (5) If both eyes are affected, a randomization method will be used to determine which single eye is included in the study; if only one eye is affected, only the affected eye will be included in the study, and the contralateral healthy eye will not be included in the healthy group.
Exclusion criteria
Exclusion criteria: 1. Healthy Group: (1) Have systemic diseases that may cause peripheral neuropathy affecting corneal sensation, including but not limited to diabetes, Parkinson's disease, multiple sclerosis, autoimmune diseases, etc.; (2) History of eye surgery, including refractive surgery, history of trauma, history of corneal foreign bodies or chemical burns; (3) History of long-term or recent (within 3 months) contact lens wear; (4) Suffering from psychiatric disorders, cognitive dysfunction, or any other condition that prevents understanding study instructions and completing subjective examinations and follow-ups; (5) Pregnant or breastfeeding women, simultaneously participating in other interventional clinical studies, or any other factors judged by the researchers to be unsuitable for participating in this study. 2. Patients with Neurotrophic Keratitis: (1) Suffering from psychiatric disorders, cognitive dysfunction, or any other condition that prevents understanding study instructions and completing subjective examinations and follow-ups; (2) Pregnant or breastfeeding women, simultaneously participating in other interventional clinical studies, or any other factors judged by the researchers to be unsuitable for participating in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal sensation threshold measured by the Dr.eye non-contact corneal aesthesiometer;The longest nylon filament length at which the cornea perceives the stimulus, measured by the Cochet-Bonnet contact corneal aesthesiometer; | — |
Countries
China
Contacts
Public ContactZelin Zhao
Eye Hospital, Wenzhou Medical University
Outcome results
None listed