Acute ischemic stroke
Conditions
Interventions
Control group :Standard early rehabilitation (equal-duration conventional training or conventional rehabilitation education, according to the unified protocol of the research center)
Experimental group :Standard Early Rehabilitation Combined with BCI Training
Sponsors
Shandong Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Ages 18–80; 2. Diagnosed with AIS and received reperfusion therapy (IVT and/or MT); if MT was performed, successful recanalization confirmed intraoperatively: eTICI 2b–3; 3. Satisfy the stability determination of the corresponding path; 4. Dominant hand ipsilateral unilateral limb dysfunction; 5. At time T0, FMA-UE scores 10–50 points (excluding overly light/heavy ceiling or floor effects, to ensure training is measurable and feasible); 6. Pre-stroke mRS <=2; 7. Sign the informed consent and be able to cooperate with training and follow-up (signed by a legal guardian if necessary);
Exclusion criteria
Exclusion criteria: 1. Imaging confirms symptomatic intracranial hemorrhage (sICH) or the investigator determines that the risk of hemorrhage is unacceptable and treatment strategy needs to be changed; 2. Obvious progressive neurological deterioration or requiring urgent intervention (e.g., NIHSS increased by =4 compared to before and the cause is unknown/unstable), not suitable for training; 3. Severe consciousness disorder, serious aphasia/neglect, or significant cognitive impairment, leading to inability to complete BCI training tasks or inability to complete primary outcome assessments; 4. Significant bilateral motor impairment (such as brainstem/bilateral lesions) or previous moderate to severe disability in the contralateral upper/lower limb, affecting training and scale interpretation within the 'unilateral involvement' framework; 5. Severe comorbidities or unstable vital signs (including but not limited to: unstable arrhythmias, severe heart failure/respiratory failure, active severe infection/sepsis, severe liver and kidney failure, etc.), where the investigator judges that it is not safe to complete training and follow-up. 6. Severe scalp skin damage/infection or other reasons preventing safe wearing of an EEG electrode cap; 7. Frequent seizures within the past 7 days randomly, or the investigator deems the risk of epilepsy unacceptable; 8. Pregnancy or breastfeeding; 9. Currently participating in other interventional clinical studies that may affect the outcomes of this study, or deemed unsuitable for enrollment by the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ?FMA-UE; | — |
Secondary
| Measure | Time frame |
|---|---|
| upper limb function;National Institutes of Health Stroke Scale;modified Rankin Scale; | — |
Countries
China
Contacts
Public ContactQinjian Sun
Shandong Provincial Hospital
Outcome results
None listed