Healthy newborns
Conditions
Interventions
Healthy newborns group:None
Critically ill neonates and children group:None
Sponsors
Chengdu Women's and Children's Center Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion Criteria for Healthy Newborn Cohort (1) In collaboration with hospitals at different altitudes within the Tibet Autonomous Region, prospectively enroll healthy, singleton, term neonates (gestational age 37–42 weeks) born to low-risk pregnant women who have resided continuously (for more than 3 months) at an altitude of >=1500 m during pregnancy. (2) Adhere to the principles of ethics and informed consent. 2. Inclusion Criteria for Critically Ill Cohort (1) Neonatal Pulmonary Diseases and Critical Illnesses (all of the following criteria must be met): 1) The mother resided at an altitude of >=1500m for more than 3 months during pregnancy. 2) The neonate is diagnosed with respiratory distress syndrome (RDS), or requires invasive mechanical ventilation, or is diagnosed with neonatal sepsis. 3) Informed consent is obtained from the legal guardian. (2) Pediatric Pulmonary Diseases and Critical Illnesses (all of the following criteria must be met): 1) Age =1500m for more than 3 months. 2) Diagnosed with severe pneumonia or sepsis. 3) Informed consent is obtained from the legal guardian.
Exclusion criteria
Exclusion criteria: 1. The legal guardian requests withdrawal, or the neonate is admitted to the neonatology department due to cardiopulmonary disease within 7 days after birth. 2. Presence of other factors that may affect the postnatal transitional period, including: (1) Maternal non-low-risk status during pregnancy or prior to delivery (according to the five-color risk management classification); (2) Any neonatal disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Echocardiographic hemodynamic Indices(including RV FAC, RV CO, LVEF, MAPSE/TAPSE, LV CO, Mitral/Tricuspid early diastolic inflow velocity, Mitral/Tricuspid late diastolic inflow velocity , Patent ductus arteriosus size / Shunt direction, RVET, PAAT,etc.);Cerebral hemodynamic indices(including PSV, EDV,RI,PI,etc.);Lung Ultrasound(six-region score);Renal, gastrointestinal, and other organ function indicators((Organ perfusion parameters)); | — |
Countries
Cina
Contacts
Public ContactJu Rong
Chengdu Women's and Children's Center Hospital
Outcome results
None listed