Female infertility
Conditions
Interventions
D2 Embryo Transfer Group:Fresh embryo transfer on day 2 after oocyte retrieval
D3 Embryo Transfer Group:Fresh embryo transfer on day 3 after oocyte retrieval
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
Female
Age
35 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.Meet the definition of POSEIDON Category 4: age = 35 years, with antral follicle count (AFC) < 5 or anti-Müllerian hormone (AMH) < 1.2 ng/mL; 2.Undergoing first or second IVF/ICSI cycle; 3.Undergoing controlled ovarian hyperstimulation (COH) using a gonadotropin-releasing hormone (GnRH) antagonist protocol, with at least 1 oocyte retrieved; 4.Provide written informed consent;
Exclusion criteria
Exclusion criteria: 1. Use of donor oocytes/sperm, or planned preimplantation genetic testing (PGT); 2. Severe immune or chromosomal abnormalities; 3. Uterine cavity abnormalities (i.e., submucous fibroids, complete uterine septum, severe intrauterine adhesions, etc.) or untreated, ultrasound-visible hydrosalpinx; 4. Presence of severe underlying diseases (e.g., uncontrolled hypertension/diabetes mellitus, active malignant tumors); 5. History of recurrent implantation failure (>=2 cycles) or recurrent miscarriage (>=2 episodes); 6. Progesterone level > 1.5 ng/mL on the day of human chorionic gonadotropin (hCG) trigger;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Congenital malformation rate;Low birth weight rate;Embryo utilization rate;Moderate/severe OHSS incidence rate;Miscarriage rate;Clinical pregnancy rate;Implantation rate;Rate of no available embryos;Biochemical pregnancy rate;Preterm birth rate;Ongoing pregnancy rate; | — |
Countries
China
Contacts
Public ContactJiang Shutian
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed