Strabismus
Conditions
Interventions
Sponsors
Eye Hospital, Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
5 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.The age range is from 5 to 50 years old, with no gender restrictions, and all applicants must be in good health. 2. Patients diagnosed with strabismus by ophthalmology professionals, with corrected vision not lower than 0.8, and the difference in the best corrected vision between the two eyes not exceeding 2 lines. 3. Wear/Do not wear corrective glasses for at least 3 months, with the lens power being the latest optometry prescription. 4. Simple strabismus, excluding thyroid-associated ophthalmopathy (TAO), orbital fractures, and previous history of ocular trauma, etc., which are diseases inherently characterized by inflammation/fibrosis; 5. No history of neurological or mental disorders such as intellectual disability, language expression disorder, or attention disorder that may affect the cooperation in the experiment; 6.The patient himself and his guardian have given informed consent, voluntarily participated in the experiment and signed the informed consent form. They are able to follow the experimental protocol and complete the follow-up.
Exclusion criteria
Exclusion criteria: 1. Craniofacial deformities involving the orbit; 2. Patients who have undergone surgery on the vertical and rotational muscles; 3. Patients with restricted or paralyzed eyes due to restrictive or paralytic strabismus; 4. Patients with severe neurological impairments, such as those with cerebral palsy; 5. Patients with mild language/learning disabilities who meet the surgical criteria;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression levels of key fibrosis genes and proteins (Piezo1/YAP/a-SMA); | — |
Countries
China
Contacts
Public ContactZhang Fang
Eye Hospital, Wenzhou Medical University
Outcome results
None listed