Postoperative delirium
Conditions
Interventions
Sham transcranial alternating current stimulation group:Electrode position: the anode is placed in the left dorsolateral prefrontal cortex (F3 area), and the cathode is placed in the right supraorbita
The vital signs and discomfort reactions of patients were monitored in the whole process to achieve double-blind control.
Alpha wave transcranial alternating current stimulation group (10Hz):Stimulation frequency: 10Hz (a wave band) current intensity: 2mA stimulation duration: 20 minutes electrode position: the anode is
The whole process of stimulation was monitored to ensure the safety of intervention.
Gamma-wave transcranial alternating current stimulation group (40Hz):Stimulation frequency: 40Hz (? wave band) current intensity: 2mA stimulation duration: 20 minutes electrode position: the anode is
Sponsors
Shifang People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. elderly patients >= 65 years old and able to communicate in oral Chinese; 2. the hospital stay is expected to be more than 3 days to ensure sufficient time for postoperative observation and evaluation; 3. the American Society of anesthesiologists (ASA) classification is II~III, which can better reflect the physical condition of patients and ensure the homogeneity of research objects; 4. it is planned to adopt the anesthesia method of Intravenous Inhalation Combined with peripheral nerve block for non cardiac surgery; 5. the patient or his legal guardian voluntarily signs the informed consent form and is willing to cooperate with the whole research process.
Exclusion criteria
Exclusion criteria: 1. patients with a history of neuropsychiatric disorders (such as Alzheimer's disease, schizophrenia, etc.) or previous history of neuropsychiatric or psychiatric disorders, and the mini mental state examination score (MMSE) is less than 15 points, have a poor foundation of cognitive function, which may affect the judgment of research results; 2. have a history of craniocerebral or scalp injury, which may affect the effect and safety of transcranial AC stimulation; 3. patients with a history of severe cardiovascular disease (such as acute myocardial infarction, severe heart failure, etc.) and severe liver or renal dysfunction (such as decompensated cirrhosis, uremia, etc.) have poor physical tolerance, which may increase the risk of the study; 4. there are metal implants in the body (such as pacemaker, cochlear implant, metal internal fixation plate, etc.), which may affect the current distribution and increase the risk of adverse reactions; 5. patients with a history of drug abuse or alcohol abuse, or communication disorders caused by vision and hearing impairment may affect the assessment and data collection during the study; 6. patients who still need intubation after surgery and are unable to carry out cognitive assessment are unable to complete the evaluation of key indicators such as postoperative delirium; 7. for patients who are allergic to benzodiazepines or have contraindications, benzodiazepines may be used for postoperative sedation, etc., and allergy or contraindications will affect the study medication and results; 8. patients who have participated in other drug experiments within one month before the operation may be interfered by other drugs, affecting the accuracy of the results of this study; 9. for patients with hemoglobin<90g/L, anemia may affect the patient's physical status and postoperative recovery, and then interfere with the research results; 10. patients who refused to sign informed consent did not meet ethical requirements and could not be included in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium;Cognitive function (MoCA);Sleep quality (PSQI);Interleukin-6 (IL-6);TNF-a;Cone like protein 1 (vilip-1);Triggering receptor 2 of myeloid cells (strem-2);Chemokine (C-C motif) ligand 2 (CCL2); | — |
Secondary
| Measure | Time frame |
|---|---|
| Arousal level (RASS);Anxiety and depression (HADS);Pain (NRS);Recovery quality (QoR-15); | — |
Countries
China
Contacts
Public ContactLin Zeng
Shifang People's Hospital
Outcome results
None listed