The main research focus is on insomnia during the perimenopausal period.
Conditions
Interventions
Combined treatment group:Based on the estrogen-progestogen replacement therapy plan formulated by the gynecologist, ultrasound-guided stellate ganglion block (SGB) treatment is administered from the f
Single treatment group:An individualized plan is formulated by collaborating gynecologists based on the 'Guidelines for Perimenopause Management and Menopausal Hormone Therapy' and the patient's speci
Dydrogesterone tablets 10mg, taken orally on days 10-14 of each menstrual cycle or treatment cycle. The specific medication regimen is subject to the gynecologist's prescription. At the 4th week, bloo
Sponsors
Qinghai Provincial People's Hospital
Eligibility
Sex/Gender
Female
Age
45 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Women aged 45-55 in the perimenopausal period (menstrual disorders: amenorrhea >= 2 months or menstrual changes >= 7 days/cycle); 2. Perimenopausal patients with sleep disorders who meet the criteria (PSQI > 5, and also meet HAMA >= 7, HAMD >= 7, FSH > 10 IU/L); 3. Long-term residents of plateau areas in Qinghai Province with an average elevation >= 2500 meters, and continuous residence time >= 5 years
Exclusion criteria
Exclusion criteria: 1. Patients with liver or kidney dysfunction; ALT > 120 U/L, Child-Pugh >= B; eGFR 106 µmol/L; 2. Thrombotic events occurred within 6 months; 3. Glycated hemoglobin > 8.5%;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum hormone levels;Insomnia Severity Rating Scale;Hamilton Anxiety Scale; | — |
Countries
China
Contacts
Public ContactYu Haiyan
Qinghai Provincial People's Hospital
Outcome results
None listed