Benign Gynecological Diseases
Conditions
Interventions
Sponsors
The Fifth People's Hospital of Huai'an, Affiliated to Yangzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female patients aged 18 to 65 years. 2. Scheduled for elective laparoscopic gynecological surgery (e.g., ovarian cystectomy, myomectomy). 3. American Society of Anesthesiologists (ASA) physical status I–III. 4. Preoperative APAIS anxiety subscale score = 12 (to ensure inclusion of anxious patients). 5. Voluntarily signed informed consent form.
Exclusion criteria
Exclusion criteria: 1.Body mass index (BMI) > 30 kg/m² or < 18 kg/m². 2.Nasal pathology (e.g., severe rhinitis, deviated nasal septum, history of recent nasal surgery) that may impair nasal mucosal absorption. 3.Severe bradycardia (HR < 50 bpm) or hypotension (SBP < 90 mmHg). 4.Long-term use of psychotropic medications (with discontinuation < 1 week). 5.Known hypersensitivity or allergy to dexmedetomidine or any of its components. 6.Pregnant or lactating women. 7.History of diagnosed psychiatric disorders (e.g., major depression, schizophrenia), cognitive impairment, or inability to cooperate with the completion of scales.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The composite incidence of PONV within 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS anxiety score;Rescue antiemetic therapy;The detailed clinical phenotype of PONV;Intraoperative opioid consumption;Quality of recovery;Patient-reported experience and satisfaction; | — |
Countries
China
Contacts
Public ContactKun Dai
The Fifth People's Hospital of Huai'an, Affiliated to Yangzhou University
Outcome results
None listed