Obstructive Sleep Apnea
Conditions
Interventions
Normal Control Group:None
Mild-to-Moderate OSAS Group:None
Severe OSAS Group:None
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Aged between 30 and 70 years old; (2) Diagnosed with obstructive sleep apnea syndrome (OSAS) via polysomnography (PSG), or enrolled in the normal control group; (3) The subjects themselves or their legal representatives have signed the informed consent form in person, and are capable of completing the depression and emotional scale ratings mentioned in the research protocol.
Exclusion criteria
Exclusion criteria: (1) patients with previous cerebrovascular diseases such as cerebral infarction, cerebral hemorrhage and other diseases; (2) intracranial or extracranial artery stenosis =50 or occlusion; (3) TCD examination could not be completed due to the lack of acoustic Windows of temporal bone on both sides. (4) The difference of blood flow velocity between bilateral MCA was greater than 20%; (5) prior treatment for sleep apnea, such as continuous airway CPAP; (6) total sleep time (TST) < 4 hours;me.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypoxic burden (HB);Functional connectivity of default mode network;Dynamic cerebral autoregulation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fractional anisotropy of white matter;Gray matter volume;Epworth Sleepiness Scale (ESS) total score;Pittsburgh Sleep Quality Index (PSQI) total score;Generalized Anxiety Disorder-7 (GAD-7) total score;STOP-BANG questionnaire total score; | — |
Countries
China
Contacts
Public ContactZhang Ning
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed