B-acute lymphoblastic leukemia
Conditions
Interventions
Treatment-naive B-ALL:None
Sponsors
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
14 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >=14 years old, treatment-naive B-ALL. 2.Abnormal clones were detected through IgH NGS during the initial bone marrow puncture examination. 3.Patients without severe organ dysfunction and chemotherapy-tolerable. 4.atients participated voluntarily.
Exclusion criteria
Exclusion criteria: 1.Patients treated with chemotherapy previously. 2.Patients who can not be treated after being evaluated by the clinical physicians, due to other malignant tumors, infections and so on. 3.Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IgH next-generation sequencing;3-year disease-free survival rate and disease-free survival rate (RFS); | — |
Secondary
| Measure | Time frame |
|---|---|
| The negative conversion rate of MRD by IgH next-generation sequencing after treatment;Overall survival time;The occurrence of treatment-related adverse reaction events;Transplantation rate and survival rate after transplantation; | — |
Countries
China
Contacts
Public ContactHuang Wei
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology
Outcome results
None listed