Exploring the Relationship Between Primary Trigeminal Neuralgia and Intestinal Flora Based on Microbiomics and Metabolomics

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600123469

Enrollment

Unknown

Registered

2026-04-27

Start date

2024-07-29

Completion date

Unknown

Last updated

2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary Trigeminal Neuralgia,

Interventions

Primary Trigeminal Neuralgia Patients:None

Healthy Volunteers:None

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 2024From March 15, 2025 to December 1, 2025, 35 patients with primary trigeminal neuralgia and 35 healthy volunteers (age, gender and educational level matched) were hospitalized in the pain department.

Exclusion criteria

Exclusion criteria: 1. Secondary trigeminal neuralgia and other types of pain disorders; 2. Use of antibiotics, hormones, immunosuppressants, anti-tumor drugs, etc., in the past month; 3. A history of chronic severe infections; 4. A history of intestinal diseases (such as inflammatory bowel disease, a history of gastrointestinal surgery, etc.); 5. Patients with other combined neurological diseases; 6. Uncontrolled mental disorders and communication disorders.

Design outcomes

Primary

Measure	Time frame
Pain intensity (Numerical Rating Scale, NRS);Pain intensity (Short-Form McGill Pain Questionnaire, SF-MPQ);Differentially expressed metabolites;Key genes;Differentially regulated signaling pathways;Gut microbiota changes;Inflammatory cytokines (IL-6, IL-1ß, TNF-a, IL-10, etc.);	—

Countries

China

Contacts

Public ContactBai Qian

The Second Affiliated Hospital of Zhengzhou University

baiqian@zzu.edu.cn+86 186 3866 0393

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026