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Prospective Intervention Study on the Effects of Low-Magnitude High-Frequency Vibration (LMHFV) on Muscle Health and Intrinsic Capacity in Elderly Patients with Sarcopenia: A Mechanistic Exploration Based on Multidimensional Biomarkers

Prospective Intervention Study on the Effects of Low-Magnitude High-Frequency Vibration (LMHFV) on Muscle Health and Intrinsic Capacity in Elderly Patients with Sarcopenia: A Mechanistic Exploration Based on Multidimensional Biomarkers

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600123467
Enrollment
Unknown
Registered
2026-04-27
Start date
2026-04-27
Completion date
Unknown
Last updated
2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sarcopenia

Interventions

Vibration Training Group:Low-intensity high-frequency vibration training

Sponsors

Zhongshan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 65 years, any gender; 2. Meet the diagnostic criteria of the 2025 Asian Working Group for Sarcopenia (AWGS) Expert Consensus, specifically fulfilling both conditions: 1) Muscle strength reduction: handgrip strength < 28 kg for males and < 18 kg for females; 2) Low muscle mass: Appendicular Skeletal Muscle Index (ASMI) assessed by Dual-energy X-ray Absorptiometry (DXA) < 7.0 kg/m² for males and < 5.4 kg/m² for females. 3. Be lucid and possess basic communication skills, capable of understanding and willing to comply with the study procedures. 4. Voluntarily participate in this study and have provided written informed consent.

Exclusion criteria

Exclusion criteria: 1. Presence of contraindications to whole-body vibration training, including but not limited to: severe arrhythmia, uncontrolled hypertension, recent deep vein thrombosis, individuals with unstable metal implants or implanted pacemakers. 2. Have severe joint diseases (e.g., advanced knee osteoarthritis) or neurological disorders (e.g., Parkinson's disease, severe hemiplegia after stroke) that prevent completion of the training movements. 3. Have severe osteoporosis or a recent history of fragility fractures (e.g., vertebral or hip fractures), presenting a high risk of fracture. 4. Have severe or unstable failure of vital organs (heart, liver, kidney, lungs, etc.) or terminal malignant tumor with an expected survival of <1 year. 5. Are currently regularly participating in other structured resistance or aerobic exercise training programs, or have participated in other interventional clinical studies within the past 3 months. 6. Have any other medical or psychological condition deemed by the investigator as unsuitable for participation in this study.

Design outcomes

Primary

MeasureTime frame
Handgrip Strength;

Secondary

MeasureTime frame
Limb muscle mass index;

Countries

China

Contacts

Public ContactWexi Wang

Zhongshan Hospital, Fudan University

wang.weixi@zs-hospital.sh.cn+86 18818210896

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026