The efficacy and safety of the tegileridine PCIA background infusion mode for postoperative analgesia in patients undergoing abdominal surgery

The efficacy and safety of the tegileridine PCIA background infusion mode for postoperative analgesia in patients undergoing abdominal surgery: A prospective clinical randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600123455

Enrollment

Unknown

Registered

2026-04-27

Start date

2026-04-30

Completion date

Unknown

Last updated

2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal tumors (liver tumors, gastrointestinal tumors)

Interventions

Background group:Tegilizidine PCIA Background Infusion Mode

Background-free group:Tegilitinib PCIA Background-Free Infusion Mode

Control group:Sufentanil PCIA Background Infusion Mode

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Patients aged 18 to 75 years old, regardless of gender; 2.Body mass index (18kg/m^2 < BMI < 30kg/m^2); 3.Patients undergoing laparoscopic abdominal tumor surgery; 4.ASA classification I to III; 5.Have signed the informed consent form;

Exclusion criteria

Exclusion criteria: 1.Chronic pain existed within one month before the surgery or any pain-relieving medication was being taken; 2.Allergic to opioid drugs; 3.History of drug and/or alcohol abuse within the past year; 4.Severe liver or kidney dysfunction (ALT and/or AST > 3 times the normal value, creatinine clearance rate < 30 mL/min), severe COPD (30% < FEV1 < 50%); 5.Long-term use of antipsychotic drugs by patients with mental disorders; 6.Currently pregnant or breastfeeding; 7.Withdrawal from PCIA or switch to other analgesic regimens; 8.The investigator believes that there are any other reasons that make the patient unsuitable to participate in this study.

Design outcomes

Primary

Measure	Time frame
Postoperative NRS scores (rest and activity);Postoperative patient satisfaction;	—

Secondary

Measure	Time frame
The time of first activation of the rescue analgesia plan after surgery and the number of rescue analgesia applications after surgery;Types and cumulative usage of postoperative rescue analgesic drugs;The consumption of PCIA drugs and Total number of PCIA presses and Number of effective PCIA compressions;Nauseous and Vomiting and swirl and Constipation;The first time one is able to get out of bed and move around and Time of anal gas expulsion;Ramsay Score;Self-assessment of sleep quality;SpO2 and Respiratory rate and Respiratory depression;Postoperative recovery quality score (QoR-15);Postoperative hospital stay;	—

Measure

Time frame

The time of first activation of the rescue analgesia plan after surgery and the number of rescue analgesia applications after surgery;Types and cumulative usage of postoperative rescue analgesic drugs;The consumption of PCIA drugs and Total number of PCIA presses and Number of effective PCIA compressions;Nauseous and Vomiting and swirl and Constipation;The first time one is able to get out of bed and move around and Time of anal gas expulsion;Ramsay Score;Self-assessment of sleep quality;SpO2 and Respiratory rate and Respiratory depression;Postoperative recovery quality score (QoR-15);Postoperative hospital stay;

—

Countries

China

Contacts

Public ContactXiong Zhangrong

Chongqing University Cancer Hospital

cqxzr0118@163.com+86 23 65075688

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026