Aging
Conditions
Interventions
Exposure group (Able to provide records of continuously and regularly taking ergothioneine dietary supplements for >=3 months (including a daily dose of 60 mg or more, frequency of four times or more
Control group (Have not taken any dietary supplements or fortified foods containing L-theanine in the past 12 months):None
Sponsors
The First People's Hospital of Hefei
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 30-75 years; 2. Grouping criteria: (1) Exposure group: Able to provide records of consistently taking L-ergothioneine dietary supplements for >=3 months (including a daily dose of 60 mg or more, at a frequency of four times per week or more). (2) Control group: Have not taken any dietary supplements or fortified foods containing L-ergothioneine in the past 12 months. 3. Voluntary participation, signing informed consent, and able to cooperate in completing indicator tests.
Exclusion criteria
Exclusion criteria: 1. Obvious cognitive decline, such as in patients with Alzheimer's disease (AD); 2. Currently undergoing chemotherapy/radiotherapy, or having disabilities or difficulties in hearing, vision, or communication; 3. Pregnant or breastfeeding women; 4. History or clinical signs of neurological disorders or psychiatric conditions, such as brain tumors, major depression, schizophrenia, etc.; 5. Skin diseases (eczema, psoriasis), muscle diseases (muscular dystrophy), or history of malignant tumors; 6. Recent (=20 cigarettes per day (1 pack), or with a smoking history >=10 years and daily smoking >=10 cigarettes; 9. Chronic heavy drinkers, averaging more than 14 units of alcohol per week (1 unit of alcohol ˜ 360 mL beer, 45 mL spirits at 40% alcohol, or 150 mL wine); 10. Experienced an acute infection requiring medication (such as upper respiratory infection, acute gastroenteritis, significant fever, etc.) within 1 month before a single visit, or are recently taking antibiotics, glucocorticoids, or other strong anti-inflammatory/immunosuppressive drugs; 11. Within 3 months before the blood draw visit, have donated whole blood (>=200 ml), received a blood transfusion, or experienced severe trauma/surgery leading to major bleeding; 12. Other situations deemed unsuitable for participation in this trial by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Epigenetic aging clock rate: DNA methylation, inflammation age; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep Assessment: Pittsburgh Sleep Quality Index (PSQI);Quality of Life Assessment: Short Form Health Survey (SF-36);Perceived Stress Scale (PSS-10); | — |
Countries
China
Contacts
Public ContactWang Shu
The First People's Hospital of Hefei
Outcome results
None listed