Chronic acute liver failure
Conditions
Interventions
Observation group of patients with liver cirrhosis in decompensated stage and acute-on-chronic liver failure:None
Observation group of compensated stage of liver cirrhosis:None
Observation group of liver cirrhosis with decompensation:None
The non-cirrhosis control observation group of the same department:None
Sponsors
Shenzhen Hospital of Southern Medical Unversity
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Non cirrhotic control patients in the same department; 2. Inclusion criteria for patients with compensated cirrhosis: (1) Agree to participate in this study and voluntarily sign an informed consent form; (2) Age 40-70 years old; (3) All patients with cirrhosis are diagnosed according to international liver disease standards, including imaging, clinical symptoms, laboratory testing or liver biopsy, medical history, and complications of cirrhosis. 3. Inclusion criteria for decompensated patients with cirrhosis: (1) Agree to participate in this study and voluntarily sign an informed consent form; (2) Patients aged 40-70 years with clear causes of cirrhosis (hepatitis B, hepatitis C, alcoholic cirrhosis); (3) All such patients are diagnosed according to international liver disease standards, including imaging, clinical symptoms, laboratory testing or liver biopsy, medical history, and complications of cirrhosis; (4) Within one month of enrollment, decompensated complications such as ascites, gastrointestinal bleeding, hepatorenal syndrome, and hepatic encephalopathy occurred. 4. Inclusion criteria for patients with decompensated cirrhosis and concomitant chronic and acute liver failure: (1) Agree to participate in this study and voluntarily sign an informed consent form; (2) Age range: 40-70 years old; (3) According to the APASL consensus definition criteria, patients with decompensated cirrhosis complicated with chronic and acute liver failure are diagnosed based on imaging, clinical symptoms, laboratory testing or liver biopsy, medical history, and complications of cirrhosis.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for patients in the compensated stage of liver cirrhosis: (1) Suffering from severe extracirrhotic diseases, including severe heart, lung and kidney dysfunction, blood diseases, malignant tumors, etc.; (2) Presenting or having experienced liver cirrhosis complications (ascites, gastrointestinal bleeding, hepatic encephalopathy, liver-kidney syndrome, etc.); (3) Participating in other clinical trials within 4 weeks prior to the start of this study; (4) Pregnant or lactating women; (5) Patients with organic mental disorders who cannot cooperate; (6) Using antibiotics, probiotics or immunosuppressants within 6 weeks; (7) Inflammatory bowel disease, acute or chronic gastrointestinal infectious diseases; (8) Complicated with severe infectious diseases such as HIV/AIDS. 2. Exclusion criteria for patients with decompensated liver cirrhosis: (1) Older than 80 years; (2) Complicated with intrahepatic or extrahepatic malignant tumors; (3) Complicated with acquired immune deficiency syndrome; (4) Undergoing immunosuppressant treatment or having immunodeficiency; (5) Refusing to sign the informed consent form; (6) The investigator deems them unsuitable to participate in this study. 3. Exclusion criteria for patients with decompensated liver cirrhosis and acute-on-chronic liver failure: (1) Older than 80 years; (2) Complicated with intrahepatic or extrahepatic malignant tumors; (3) Complicated with acquired immune deficiency syndrome; (4) Undergoing immunosuppressant treatment or having immunodeficiency; (5) Refusing to sign the informed consent form; (6) The investigator deems them unsuitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Laboratory test results;Abdominal imaging examination;Medical history and physical examination (including vital signs, height, weight, BMI); | — |
Countries
China
Contacts
Public ContactWang Anjiang
Shenzhen Hospital of Southern Medical Unversity
Outcome results
None listed