Brain neurological disorders
Conditions
Interventions
Healthy control group:Oral administration of BST01 solution (deuterium-labeled glucose, D-glucose-6,6'-d2), and MRI examination performed before and after oral administration.
Glioma group:Oral administration of BST01 solution (deuterium-labeled glucose, D-glucose-6,6'-d2), and MRI examination performed before and after oral administration.
AD group:Oral administration of BST01 solution (deuterium-labeled glucose, D-glucose-6,6'-d2), and MRI examination performed before and after oral administration.
PD group:Oral administration of BST01 solution (deuterium-labeled glucose, D-glucose-6,6'-d2), and MRI examination performed before and after oral administration.
Stroke group:Oral administration of BST01 solution (deuterium-labeled glucose, D-glucose-6,6'-d2), and MRI examination performed before and after oral administration.
Sponsors
Hainan General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Healthy volunteers: (1) Aged 18 years or older; (2) No cognitive impairment; (3) No history of head trauma or craniocerebral surgery; (4) No history of stroke, cerebral hemorrhage, brain tumor, or intracranial infection; (5) Exclusion of other types of dementia, such as dementia caused by Parkinson's disease, frontotemporal dementia, dementia with Lewy bodies, etc.; (6) No history of mental illness; (7) No history of alcohol or drug abuse; (8) Not taking any medication; (9) No alcohol or caffeinated beverages on the day of examination. 2. Glioma volunteers: (1) Aged 18 years or older; (2) Patients with high suspicion of glioma; (3) No history of head trauma or craniocerebral surgery; (4) No history of stroke, cerebral hemorrhage, or intracranial infection; (5) No preoperative radiotherapy or chemotherapy. 3. Alzheimer's disease (AD) volunteers: (1) Aged over 50 years; (2) Cognitive scores meeting the diagnostic criteria for AD; (3) No history of head trauma or craniocerebral surgery; (4) No history of stroke, cerebral hemorrhage, brain tumor, or intracranial infection; (5) Exclusion of other types of dementia, such as dementia caused by Parkinson's disease, frontotemporal dementia, dementia with Lewy bodies, etc.; (6) No history of mental illness; (7) No history of alcohol or drug abuse. 4. Parkinson's disease (PD) volunteers: (1) Aged over 18 years; (2) Meeting the diagnostic criteria for primary Parkinson's disease; (3) Hoehn and Yahr (H-Y) stage 2–4; (4) No history of head trauma or craniocerebral surgery; (5) No history of stroke, cerebral hemorrhage, brain tumor, or intracranial infection; (6) No history of mental illness; (7) No history of alcohol or drug abuse. 5. Stroke volunteers: (1) Meeting the diagnostic criteria for acute ischemic stroke as specified in the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018; (2) Onset time =18 years; (4) Hachinski Ischemic Scale (HIS) score >=7; (5) No cognitive decline or other neurological diseases prior to onset; (6) Exclusion of individuals with severe aphasia, dysarthria, or hearing impairment that may affect cognitive function assessment; (7) Exclusion of those with mental disorders or other types of dementia, or other diseases that may cause cognitive impairment (e.g., multiple sclerosis, brain tumor, encephalitis, traumatic brain injury, depression, etc.).
Exclusion criteria
Exclusion criteria: All healthy volunteers and those with suspected glioma or Alzheimer's disease (AD) enrolled in this experiment who have any contraindications to MR examination will be excluded from participating. These contraindications include: having a cardiac pacemaker implant, presence of metal implants, claustrophobia, being pregnant or breastfeeding, having diabetes, inability to lie flat for one hour or longer, body weight greater than 136 kg, history of craniocerebral surgery or traumatic brain injury, concurrent other neurological diseases besides the disease under study, and history of mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glucose uptake;glutamine/glutamate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lactate/lipid; | — |
Countries
China
Contacts
Public ContactFeng Chen
Hainan General Hospital
Outcome results
None listed