The agitation during the awakening period of children
Conditions
Interventions
Exposure group (Dexmedetomidine):None
Non-exposed group:None
Sponsors
Liuzhou people's hospital
Eligibility
Sex/Gender
All
Age
2 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Age: 2-12 years old (calculated based on birthday), covering early childhood to school age to assess recovery differences at different stages of development. 2. ASA grade: Grade I (healthy patients) or Grade II (mild systemic disease with no functional limitations, such as well-controlled asthma or mild obesity). 3. Type of surgery: Elective surgery, expected to last 30-120 minutes, such as inguinal hernia repair, circumcision, tonsillectomy, or minor ENT surgery, which are common in children and have a low risk of anesthesia. 4. Cooperative ability: The child can basically cooperate with medical procedures (such as through games or communication assessments) in the preoperative evaluation, or the parent/guardian can provide reliable information. 5. Informed consent: Written informed consent signed by parents or legal guardians; for children aged 8 years and older, additional informed consent from the child shall be obtained, using age-appropriate explanations for informed information.
Exclusion criteria
Exclusion criteria: 1. Drug allergy: Known history of allergic reaction to dexmedetomidine, propofol, remifentanil, sufentanil or related drugs. 2. Severe comorbidities: including cardiovascular disease (such as congenital heart disease, heart failure), respiratory disease (such as uncontrolled asthma, sleep apnea), liver or kidney insufficiency. 3. Neurological or psychiatric disorders: such as epilepsy, cerebral palsy, developmental delay, or autism spectrum disorder, which may affect the assessment of recovery quality. 4. History of drug use: Use of central nervous system drugs (such as benzodiazepines, antidepressants, opioids) within 1 month before surgery to avoid interactions. 5. Anesthesia risk factors: expected difficult airway (Mallampati score grade III-IV), morbid obesity (body mass index >95th percentile for the same age), or excessive surgical complexity (such as cardiothoracic surgery), or postoperative need for ICU monitoring, etc. 6. Others: Recent (within 3 months) participation in other clinical trials, or parents/guardians unable to cooperate with follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FLACC score;The duration of stay in the PACU (Post-Anesthesia Care Unit);PAED score;PedSQoR score;The time of awakening; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence rate of adverse events (such as bradycardia);The incidence rate of PONV;The first time requesting pain medication;Total dosage of analgesics; | — |
Countries
China
Contacts
Public ContactYu Xiangdi
Liuzhou people's hospital
Outcome results
None listed