Patients undergoing total mastectomy
Conditions
Interventions
Remimazolam + Propofol group:Intravenous sufentanil 0.3µg/kg, followed by intravenous remimazolam 0.1 mg/kg. Target-controlled infusion (TCI) of propofol is started 2 minutes later.
Midazolam + Propofol group:Intravenous sufentanil 0.3µg/kg, followed by intravenous midazolam 0.05 mg/kg. Target-controlled infusion (TCI) of propofol is started 2 minutes later.
Propofol alone group:Intravenous sufentanil 0.3µg/kg, followed by intravenous normal saline 5ml. Target-controlled infusion (TCI) of propofol is started 2 minutes later.
Sponsors
Jieyang People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Planned elective unilateral total mastectomy; 2. Patient and their legal representative voluntarily participate in the study and have signed the informed consent form; 3. Preoperative ASA (American Society of Anesthesiologists) classification: Class I–II; 4. Age: 18–75 years; 5. Have not participated in other drug clinical trials in the 3 months prior to surgery.
Exclusion criteria
Exclusion criteria: 1. History of allergy to related experimental drugs; 2. Severe liver and kidney dysfunction (Child-Pugh class C or eGFR <30 mL/min); 3. BMI =35 kg/m^2; 4. Long-term use of benzodiazepines or opioids; 5. Preoperative cognitive impairment (MoCA <26 points); 6. History of alcohol or drug abuse; 7. Difficult airway; 8. Pregnant or breastfeeding women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension during induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of induction and recovery profile(Record the time of loss of consciousness, endotracheal intubation condition score, total propofol induction dose, and postoperative spontaneous breathing recovery time, extubation time, and orientation recovery time); | — |
Countries
China
Contacts
Public ContactZhexuan Chen
Jieyang People's Hospital
Outcome results
None listed