None
Conditions
Interventions
Liberal fluid management group:None
Restrictive fluid management group:None
Sponsors
Wuxi people’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age 18–75 years; 2.Acute subdural/epidural hematoma, cerebral contusion-laceration, or diffuse axonal injury confirmed by computed tomography (CT); 3.Underwent emergent craniotomy for hematoma evacuation and/or decompressive craniectomy within 24 hours post-injury; 4.Intraoperative fluid management data complete (>=95% completeness in records of crystalloid volume, colloid volume, urine output, blood loss, and transfused blood volume; 5.ntracranial pressure (ICP) monitoring probe inserted postoperatively with effective monitoring duration >=72 hours; 6.Head Abbreviated Injury Scale (AIS) score >=3, representing the most severe injury region.
Exclusion criteria
Exclusion criteria: 1.Preoperative brain herniation leading to respiratory and cardiac arrest; 2.Severe preoperative shock uncorrected (mean arterial pressure 1 hour and lactate >4 mmol/L; 3.History of prior craniocerebral surgery; 4.Concomitant severe cerebrovascular malformation; 5.Intraoperative death;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ICP at the end of surgery and ICP 2 hours after surgery, ICP monitoring: Measure ICP value at the end of surgery and ICP 2 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| length of hospital stay;Neurological functional prognosis;The average ICP values and peak ICP values at 6 hours, 24 hours, 48 hours, and 72 hours after surgery;Postoperative biochemical examination(Blood biochemical tests include white blood cell (WBC), red blood cell (RBC), platelet (PLT), blood gas (pH, PaO2, PaCO2), alanine aminotransferase (ALT), creatinine (Cr), and C-reactive protein (CRT));tracheotomy rate;ICU stay duration;mortality rate; | — |
Countries
China
Contacts
Public ContactQiyao Zhang
Wuxi people’s Hospital
Outcome results
None listed