Diabetic Foot Ulcer
Conditions
Interventions
Control group:None
Diabetic Foot Ulcer (DFU) group:None
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years, regardless of gender; 2. DFUs group: Meet the diagnostic criteria for type 2 diabetes mellitus in Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes Mellitus, complicated with foot ulcers (Wagner grade 1–5), and requiring surgical debridement; 3. Control group: Normal oral glucose tolerance test results (fasting blood glucose < 6.1 mmol/L, 2-hour postprandial blood glucose < 7.8 mmol/L), with non-diabetic foot ulcers (e.g., traumatic, venous, arterial ischemic ulcers, etc.), and requiring surgical debridement; 4. Voluntarily sign the informed consent form and be able to cooperate with sample collection and collection of relevant clinical data; 5. No severe cardiac, hepatic or renal insufficiency, no malignant tumors, autoimmune diseases or other serious underlying diseases that may affect the study results.
Exclusion criteria
Exclusion criteria: 1. Patients diagnosed with type 1 diabetes or specific types of diabetes (e.g., gestational diabetes mellitus, secondary diabetes, etc.); 2. Foot ulcers caused by malignant ulcers, tuberculous ulcers, or other specific infections (e.g., fungal, syphilitic, etc.); 3. Patients who have received medications that may affect DCN expression (such as immunosuppressants, glucocorticoids) within the past 3 months; 4. Patients with cognitive dysfunction, mental illness, or other conditions that prevent cooperation with the study; 5. Pregnant or lactating females; 5. Patients currently participating in other clinical trials or who have participated in other interventional studies within the recent 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DCN expression level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wagner grading of diabetic foot ulcer;tissue inflammatory infiltration;tissue collagen remodeling;diagnostic efficacy of DCN; | — |
Countries
China
Contacts
Public ContactMingwei Chen
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed