Critically ill patients requiring bundle therapy for mechanical ventilation
Conditions
Interventions
Experimental Group:Remimazolam besylate is administered for sedation therapy
Control Group:Midazolam Injection is administered for sedation
Sponsors
second hospital of shanxi medical university
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Age >=18 years old; 2.Clinically requiring receipt of bundle therapy for mechanical ventilation for a duration of >= 3 days; 3.The patient voluntarily signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with cerebrovascular sequelae or cognitive impairment who are unable to communicate; 2.Patients allergic to sedative and analgesic drugs; 3.Pregnant and lactating women; 4.Patients with second or third degree atrioventricular block those in the acute stage of myocardial infarction those with severe bradycardia those with left ventricular ejection fraction < 0.30; 5.Hemodynamically unstable patients patients with liver dysfunction classified as Child-Pugh Class C 6.those unable to cooperate with the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| delirium;Richmond Agitation-Sedation Scale Score?Visual Analogue Scale Score;Duration of Mechanical Ventilation?Time to Extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Hemodynamic Indicators;adverse event; | — |
Countries
China
Contacts
Public Contactwangxiaoru
second hospital of shanxi medical university
Outcome results
None listed