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Vitamin D-VDR Regulates Nrf2 Pathway to Inhibit Sevoflurane-Induced Neuronal Ferroptosis: Mechanism and Perioperative Neuroprotection

Vitamin D-VDR Regulates Nrf2 Pathway to Inhibit Sevoflurane-Induced Neuronal Ferroptosis: Mechanism and Perioperative Neuroprotection

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600123385
Enrollment
Unknown
Registered
2026-04-26
Start date
2025-09-08
Completion date
Unknown
Last updated
2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperativedelirium

Interventions

Delirium group :None

Sponsors

Tianjin Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Years to 6 Years

Inclusion criteria

Inclusion criteria: No gender restrictions; children aged 3–6 years; scheduled laparoscopic surgery under general anaesthesia; American Society of Anesthesiologists (ASA) classification I–II; both the child and their guardian are fully informed about the study and have signed the consent form.

Exclusion criteria

Exclusion criteria: 1.The child has undergone general anesthesia surgery 2.Those with respiratory diseases such as upper respiratory tract infection and a history of asthma in the past two weeks 3.Those with cardiac insufficiency such as congenital heart disease and congenital dysplasia 4.Those with severe liver and kidney diseases 5.Those with a body mass index (BMI) >= 30 6.Children with dysgnosia, developmental delay, and mental illnesses

Design outcomes

Primary

MeasureTime frame
Serum 25(OH)D3 level;the pediatric anesthesia emergence delirium scale;Cornell assessment of pediatric delirium;children’s sleep habits questionnaire;

Countries

China

Contacts

Public ContactLili

Tianjin Children's Hospital

xiaoyatoulili0919@163.com+86 87787446

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026