Predicting Microsatellite Instability and Peritumoral Deposits in Rectal Cancer Using Synthetic Magnetic Resonance Imaging

Diagnostic Performance of Synthetic Magnetic Resonance Imaging for Preoperative Prediction of Microsatellite Instability Status and Peritumoral Deposits in Rectal Cancer: A Prospective Study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600123382

Enrollment

Unknown

Registered

2026-04-26

Start date

2025-03-04

Completion date

Unknown

Last updated

2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rectal Cancer

Interventions

Gold Standard:Postoperative pathological evaluation. Microsatellite instability (MSI) status is determined by immunohistochemical analysis of mismatch repair proteins (MLH1, MSH2, MSH6, PMS2) expressi

Index test:Synthetic Magnetic Resonance Imaging (Synthetic MRI). The preoperative synthetic T1-mapping, T2-mapping, and PD-mapping quantitative parameter maps are analyzed to predict microsatellite in

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1.Age >=18 years; 2.Preoperative pathological confirmation of rectal adenocarcinoma by colonoscopic biopsy; 3.Scheduled to undergo radical surgical resection for rectal cancer at a participating center; 4.Has routinely completed a preoperative pelvic MRI examination that includes the synthetic MRI sequence; 5.Voluntarily participates in the study and provides written informed consent.

Exclusion criteria

Exclusion criteria: 1.Previous history of pelvic radiotherapy or surgery; 2.Presence of any surgical contraindication; 3.Presence of any MRI contraindication (e.g., cardiac pacemaker, ferromagnetic implants, claustrophobia); 4.Incomplete MRI sequences or poor image quality that precludes diagnostic evaluation; 5.Absence of microsatellite instability (MSI) test results (lack of mismatch repair protein testing) or unknown peritumoral deposits (TDs) status.

Design outcomes

Primary

Measure	Time frame
Diagnostic performance of synthetic magnetic resonance imaging for predicting microsatellite instability status in rectal cancer;Diagnostic performance of synthetic magnetic resonance imaging for predicting peritumoral deposits in rectal cancer;	—

Secondary

Measure	Time frame
Comparison of image quality between synthetic T2-weighted imaging and conventional T2-weighted imaging;Comparison of preoperative T staging diagnostic accuracy between synthetic T2-weighted imaging and conventional T2-weighted imaging;	—

Countries

China

Contacts

Public ContactSONG, Bin

West China Hospital, Sichuan University

songlab_radiology@163.com+86 28 8542 3680

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026