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The influence of different pneumoperitoneum pressures on perioperative neurocognitive dysfunction in patients undergoing laparoscopic colorectal cancer surgery

The influence of different pneumoperitoneum pressures on perioperative neurocognitive dysfunction in patients undergoing laparoscopic colorectal cancer surgery

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600123381
Enrollment
Unknown
Registered
2026-04-26
Start date
2025-09-02
Completion date
Unknown
Last updated
2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer

Interventions

experimental group:The pneumoperitoneum pressure is between 8 mmHg and 10 mmHg
control group:The pneumoperitoneum pressure is between 12 mmHg and15 mmHg

Sponsors

Guizhou Medical University Affiliated Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for laparoscopic resection of rectal or colon cancer under general anesthesia at our hospital; 2. Age =18 years, ASA classification I, II, or III, BMI: 18-30 kg/m^2; 3. Understand the content of the informed consent form, are willing to participate in this survey, and sign the informed consent form; 4. No cognitive impairment before surgery, clear consciousness, and capable of independent actions.

Exclusion criteria

Exclusion criteria: 1. Patients with a history of central nervous system diseases, cerebrovascular diseases, language or hearing impairments, or those deemed by the investigator as unsuitable for participation in this trial; 2. Patients who have been taking psychiatric medications long-term; 3. Patients with ASA classification IV or above; 4. Patients with severe liver or kidney dysfunction before surgery.

Design outcomes

Primary

MeasureTime frame
Postoperative delirium incidence rate;

Secondary

MeasureTime frame
Telephone version of Montreal Cognitive Assessment,T-MoCA;Postoperative pain score;rScO2;mean arterial pressure,MAP;Postoperative nausea and vomiting incidence and recovery quality;C-reactive protein;NLR;PaCO2;heart rate,HR;procalcitonin,PCT;

Countries

China

Contacts

Public ContactShi Jing

Guizhou Medical University Affiliated Hospital

315585290@qq.com+86 186 8503 4016

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026