Major Depression Disorder
Conditions
Interventions
Interference group:Positive Cue-Targeted Memory Reactivation
Extinction group:Negative Cue-Targeted Memory Reactivation
Neutral Control Group:Neutral Cue-Targeted Memory Reactivation
Sponsors
Beijing HuiLongGuan Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 25 Years
Inclusion criteria
Inclusion criteria: 1.Meeting the diagnostic criteria for depression according to DSM-5; 2. All patients have undergone rigorous clinical testing and medical history review, with no history of manic, mixed, or hypomanic episodes during the entire disease course, the current diagnosis is unipolar depressive episode; 3.Aged 12–25 years, with no reading or writing impairment in Chinese; 4. Body Mass Index (BMI) not exceeding the age- and gender-specific overweight standards as defined in the "Guidelines for Weight Management" (2024 edition); 5.Normal or corrected-to-normal vision; 6. Voluntary participation in the study, with signed informed consent; 7.No history of electroconvulsive therapy in the past six months; 8.Right-handed.
Exclusion criteria
Exclusion criteria: 1. Presence of severe sleep-onset problems: In the past week, experiencing sleep latency >1.5 hours for more than 2 days, single-day sleep latency >3 hours, nighttime awakenings >2 times, average nighttime sleep duration <6 hours, or single-day nighttime sleep duration <5 hours; 2.Comorbidity with obstructive sleep apnea syndrome or restless legs syndrome; 3.Previous history of neurological disorders, alcohol or drug abuse; 4.Previous diagnosis or current suspicion of schizophrenia spectrum disorders; 5. Impulsive excitement, severe deterioration, or uncooperativeness; 6.Presence of suicidal behavior or severe suicidal ideation; 7.Serious physical illness or drug side effects; 8.Inability to cooperate with the study due to personal reasons or functional decline.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Image Emotion-Cognitive Valence;Picture Recognition Memory Accuracy; | — |
Countries
China
Contacts
Public ContactShuping Tan
Beijing HuiLongGuan Hospital
Outcome results
None listed