Depression (MDD) is a group of mental disorders with low mood, diminished interest and lack of willpower as the main symptoms. According to the World Health Organisation (WHO), about 350 million people worldwide are affected by depression, with a global prevalence rate of 4.4%, and depression has gradually become one of the major causes of disability worldwide.
Conditions
Interventions
Drug-naive Group (Training set):None
Drug-treated Group (Training set):None
Healthy Control Group (Training set):None
Drug-naive Group (Validation set):None
Drug-treated Group (Validation set):None
Healthy Control Group (Validation set):None
Sponsors
Wuxi Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Conform to or reach the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition DSM-5 and The eleventh edition of the international Classification of Diseases (the eleventh revision) The first diagnostic criteria for depression in ICD-11 and not having received psychiatric drug treatment; 2. Chinese Han residents, aged between 18 and 65 years old; 3. Primary school education or above; 4. The score of the 17-item Hamilton Depression Scale (HAMD-17) is >=17 points; 5. Voluntarily participate in the research and sign the informed consent form. (1) Meeting or reaching the diagnostic criteria for depression as stipulated in DSM-5 and ICD-11, and having received antidepressant drug treatment for at least 2 weeks with stable condition; (2) Chinese Han residents, aged between 18 and 65 years old; (3) Primary school education or above; (4) HAMD-17 points >=17 points; (5) Voluntarily participate in the research and sign the informed consent form. 1) HAMD-17 score <=7 points, no personal or family history of mental illness, and no history of taking psychiatric drugs; 2) Chinese Han residents, aged between 18 and 65 years old; 3) Primary school education or above; 4) Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Suffering from other mental disorders diagnosed by DSM-5 and ICD-11, such as schizophrenia, bipolar disorder, personality disorder, etc. 2. Patients with any previous history of modified electroconvulsive therapy (MECT). 3. Combined with serious physical diseases, such as coronary heart disease, thyroid dysfunction, etc. 4. There has been a history of craniocerebral trauma or epilepsy that led to loss of consciousness; 5. Has a history of drug or substance abuse/dependence; 6. Women who are pregnant, lactating or in the stage of preparing for pregnancy (childbearing); 7. Recently, there have been conditions such as fever, acute infection or infectious diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differential platelet-derived exosome protein expression profile;Candidate biomarkers;Diagnostic model performance metrics (AUC, sensitivity, specificity);Hamilton Depression Rating Scale-17 (HAMD-17) score;Montgomery-?sberg Depression Rating Scale (MADRS) score;Exosome characteristic markers (CD9, CD63, CD81);Exosome size distribution;Exosome morphology; | — |
Secondary
| Measure | Time frame |
|---|---|
| General demographic data (age, sex, BMI, education level, etc.); | — |
Countries
China
Contacts
Public ContactYang Zimeng
Wuxi Mental Health Center
Outcome results
None listed