Postoperative delirium (POD)
Conditions
Interventions
POD-High risk:None
POD-low risk:None
Sponsors
Shanghai Chest Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years; 2. Elective major cardiac or great vessel surgery requiring cardiopulmonary bypass (CPB); 3. Normal preoperative cognitive function, defined as Mini-Mental State Examination (MMSE) score >=24; 4. Expected cardiopulmonary bypass duration >=1 hour.
Exclusion criteria
Exclusion criteria: 1. Patients with a preoperative MMSE score <24; 2. Patients with a history of severe psychiatric disorders or epilepsy; 3. Patients who received high-dose glucocorticoids or immunosuppressive/biologic therapy within 14 days before surgery; 4. Patients with ALT, AST, or total bilirubin (TBi) exceeding three times the upper limit of normal; 5. Patients with serum creatinine exceeding twice the upper limit of normal; 6. Pregnant or breastfeeding women; 7. Patients with known platelet function disorders; 8. Patients unwilling to participate in the study or unable to provide informed consent; 9. Patients unable to undergo CAM-ICU assessment within 24–72 hours postoperatively for any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Baseline platelet activation level;Platelet response to ADP;CAM-ICU–based delirium assessment outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Core temperature;Intraoperativebloodtransfusion;5-HT;IL-6;Platelet metabolites detected by LC-MS;Preoperative use of antiplatelet drugs;TXA2;MAP; | — |
Countries
China
Contacts
Public ContactWu Jingxiang
Shanghai Chest Hospital
Outcome results
None listed