Helicobacter pylori infection
Conditions
Interventions
Control group:The control group will receive the standard bismuth quadruple therapy
experimental group:the experimental group will add the Bovis yeast powder to the standard bismuth quadruple therapy
Sponsors
The First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years, any gender. 2. Patients diagnosed with confirmed H. pylori infection, confirmed by gastric biopsy rapid urease test (RUT) or ^13C/^14C urea breath test (UBT) through endoscopy. 3. Meet the treatment standards recommended by the "Sixth National Consensus Report on Helicobacter pylori Infection Management" and meet the indications for standard bismuth quadruple therapy. 4. Subjects voluntarily sign the informed consent form, can follow up on time, and adhere to the treatment plan. 5. Have not previously received formal H. pylori treatment.
Exclusion criteria
Exclusion criteria: 1. History of gastrectomy, gastric cancer, or other malignant tumors. 2. Severe cardiac, hepatic, or renal dysfunction, or having immune system diseases (such as HIV infection or autoimmune diseases). 3. Recent use of antibiotics, bismuth agents, probiotics, or PPIs that may affect Hp test results. 4. Allergy-prone individuals or those with a history of allergy to study drugs (amoxicillin, clarithromycin, bismuth agents, Saccharomyces boulardii). 5. Past or current pyloric obstruction, gastrointestinal perforation, or hemorrhagic diseases, or concomitant severe gastrointestinal diseases (such as Crohn's disease or ulcerative colitis). 6. Pregnant or breastfeeding women, or those planning pregnancy. 7. Poor compliance, unable to complete study follow-up or medication regimen on time.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| HP eradication rate;Incidence of adverse reactions and symptom relief;Inflammatory cytokine levels;Pepsinogen levels; | — |
Countries
China
Contacts
Public ContactZhang Zhiqiang
The First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed