mitral regurgitation
Conditions
Interventions
Exposure group:None
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Able to understand the research content, voluntarily participate, and sign a written informed consent form. 2. Committed to following the research procedures and willing to cooperate in completing the entire study process, including baseline assessments, regular imaging examinations, and long-term clinical follow-up. 3. Age >= 18 years. 4. Diagnosed with primary or secondary mitral regurgitation based on echocardiography, according to the standards of the American Society of Echocardiography (ASE) guidelines for the management of valvular heart disease. 5. Possess complete baseline clinical data (such as medical history, vital signs, key laboratory test results, etc.) available for collection. 6. Able to cooperate with multi-modal imaging examinations required for the study (mainly transthoracic echocardiography) and obtain images of sufficient quality for quantitative analysis.
Exclusion criteria
Exclusion criteria: 1. Any condition that may increase the risk of transthoracic echocardiography or make the examination impossible (such as severe thoracic deformity, extensive subcutaneous emphysema, open chest wall wounds, etc.). 2. Recent history of active bleeding (e.g., within the past 3 months), or uncontrolled high risk of bleeding. 3. Any uncontrolled severe systemic disease, including but not limited to: severe liver dysfunction (e.g., Child-Pugh class C), severe renal insufficiency (e.g., estimated glomerular filtration rate eGFR < 30 mL/min/1.73m² or on maintenance hemodialysis), end-stage pulmonary disease (e.g., requiring long-term oxygen therapy). 4. Active or untreated malignant tumors (excluding local low-grade malignancies such as basal cell carcinoma of the skin), or any advanced disease with an expected life expectancy of less than 1 year. 5. Severe cardiac valve disease requiring intervention other than mitral regurgitation (e.g., severe aortic stenosis/regurgitation). History of heart transplantation or left ventricular assist device implantation. Comorbidities affecting cardiac structure and function assessment, such as constrictive pericarditis, restrictive cardiomyopathy, severe congenital heart disease, etc. Atrial fibrillation with poor ventricular rate control, or other persistent severe arrhythmias, leading to inability to standardize ultrasound image acquisition and measurements. 6. Expected poor compliance with the study, such as inability to cooperate with the examination, inability to provide reliable contact information, plans to move out of the area, or explicitly expressing inability to complete long-term follow-up. 7. Upon assessment, poor ultrasound image quality that cannot meet the reliable quantitative analysis requirements for core parameters (such as left ventricular volume, ejection fraction, myocardial strain, etc.). 8. Pregnant or breastfeeding women, or those planning to become pregnant during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left Ventricular Global Longitudinal Strain (LV GLS);Global Work Index (GWI); | — |
Countries
China
Contacts
Public ContactJing Wang
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed