thyroid tumor
Conditions
Interventions
Phase 2: Ciprofol group:Ciprofol target-controlled infusion
Phase 2: Propofol group:Propofol target-controlled infusion
Phase 1 Group A (20-39 years old):Ciprofol plasma target-controlled induction, initial concentration 3.5 µg/ml.
Phase 1 Group B (40-59 years old):Ciprofol plasma target-controlled induction, initial concentration 3.0 µg/ml.
Phase 1 Group C (60-79 years old):Ciprofol plasma target-controlled induction, initial concentration 2.5 µg/ml.
Sponsors
chongqing university cancer hospital
Eligibility
Sex/Gender
All
Age
20 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade ?, grade ?; 2. Patients or their family members agree and sign the informed consent form; 3. BMI 18–30 kg/m²; 4. Normal liver and kidney function; 5. No preoperative use of sedative medications or alcohol consumption. 6. Age meets the grouping criteria. 7. Patients undergoing elective thyroid surgery (Phase 2);
Exclusion criteria
Exclusion criteria: 1. Patients undergoing emergency surgery; 2. Presence of cardiopulmonary disease (NYHA functional class = II); 3. Previous allergy to ciprofol or propofol; 4. Pregnancy or lactation. 5. Predicted difficult airway (Mallampati class III/IV or history of head/neck surgery, etc.); 6. QTc interval >=450 ms; 7. Use of drugs within 2 weeks prior to surgery that may affect QT interval or induce/inhibit cytochrome P450 enzymes (especially CYP2B6), such as strong inhibitor efavirenz, moderate inhibitors clopidogrel and paroxetine, weak inhibitors fluoxetine and sertraline.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of total intravenous anesthesia induction and maintenance(Phrase 2);Plasma concentration (Cp) for successful induction and the corresponding effect-site concentration (Ce); | — |
Countries
China
Contacts
Public ContactHaijian Shen
chongqing university cancer hospital
Outcome results
None listed