Hyperalgesia
Conditions
Interventions
Control group:After skin incision, an equal volume of 0.9% normal saline was administered via intravenous infusion pump.
Ciprofol group:After skin incision, ciprofol was continuously infused intravenously at a dose of 0.3 mg/kg/h via infusion pump.
Sponsors
Affiliated Qingyuan Hospital, Guangzhou Medical University,Qingyuan People's Hospital;
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Voluntarily participate in this study and sign the informed consent form in person; 2.Aged 18–65 years, female; 3.Scheduled to undergo laparoscopic gynecological surgery under general anesthesia (including but not limited to laparoscopic myomectomy, total hysterectomy, etc.); 4.American Society of Anesthesiologists (ASA) physical status class I–II; 5.Mallampati class < 3; 6.Body mass index (BMI) ranging from 18.5 to 28 kg/m²; 7.Estimated operative time 2–3 hours.
Exclusion criteria
Exclusion criteria: 1.Known history of chronic pain or acute exacerbation of chronic pain; 2.History of abuse or dependence of anesthetic or sedative drugs (including opioids, benzodiazepines, etc.); 3.Previous history of coronary artery bypass grafting, active gastrointestinal bleeding, or gastrointestinal perforation; 4.Presence of severe arrhythmias such as severe bradycardia and bundle branch block; 5.History of psychiatric disorders; 6.History of difficult airway or delayed extubation (previous postoperative extubation time > 2 hours); 7.Definite history of allergy to any drugs used in this study; 8.Use of opioid analgesics or other drugs that may affect pain perception (e.g., antidepressants, antiepileptics) within 7 days preoperatively; 9.Preoperative cognitive dysfunction; 10.Complicated with severe systemic diseases: severe cardiovascular disease (NYHA class III or above), severe pulmonary disease, or hepatic and renal dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs;Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale;Sleep quality;Adverse reaction occurrence;Mechanical pain threshold;Total length of stay;Analgesic drug usage; | — |
Countries
China
Contacts
Public ContactBaojun Fu
Affiliated Qingyuan Hospital, Guangzhou Medical University,Qingyuan People's Hospital
Outcome results
None listed