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The Impact of G6PD Gene Mutations on HbA1c Underestimation and Cardiocerebrovascular Outcomes in Patients with Type 2 Diabetes Mellitus: A Multicenter Cohort Study

The Impact of G6PD Gene Mutations on HbA1c Underestimation and Cardiocerebrovascular Outcomes in Patients with Type 2 Diabetes Mellitus: A Multicenter Cohort Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600123323
Enrollment
Unknown
Registered
2026-04-24
Start date
2026-07-01
Completion date
Unknown
Last updated
2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus

Interventions

G6PD mutation group:None

Sponsors

The Fifth Affiliated Hospital of Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1: Meet the diagnostic criteria for type 2 diabetes mellitus (T2DM) according to the Guideline for the Prevention and Treatment of Type 2 Diabetes in China (2020 edition);. 2: Aged 18 to 75 years; 3: HbA1c and fasting plasma glucose tests completed concurrently during the index hospitalization (blood collection interval =3 days); 4: Have residual peripheral blood samples available for G6PD genetic testing; 5: Have complete clinical data.

Exclusion criteria

Exclusion criteria: 1: Type 1 diabetes mellitus, gestational diabetes mellitus, or secondary diabetes 2: Receipt of blood transfusion or erythropoietin therapy within 3 months prior to enrollment 3: Confirmed non-G6PD-related hemolytic anemia, thalassemia, or other serious hematological disorders 4: End-stage renal disease (eGFR <15 mL/min/1.73m^²) or undergoing renal replacement therapy; 5: Concomitant malignancy or severe liver failure (Child-Pugh class C) 6: Missing more than 20% of key variables in medical records

Design outcomes

Primary

MeasureTime frame
Hemoglobin A1c;G6PD gene mutation status;

Countries

China

Contacts

Public ContactSunwuping

The Fifth Affiliated Hospital of Southern Medical University

wuping.sun@foxmail.com+86 135 9023 1245

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026