Heart disease
Conditions
Interventions
Group A:Intraoperative continuous infusion of dexmedetomidine
Group B:Continuous intraoperative infusion of an equal volume of normal saline
Sponsors
The First Affiliated hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients scheduled to undergo CPB heart valve replacement surgery under general anesthesia were included in this study.
Exclusion criteria
Exclusion criteria: 1. Refusal to provide written informed consent; 2. History of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or severe dementia before surgery; 3. Unable to communicate due to visual, hearing, speech, or other impairments; 4. Severe liver failure (Child-Pugh class C) or history of liver surgery; 5. Left ventricular ejection fraction <30%; 6. Severe renal failure (requiring renal replacement therapy); 7. Contraindications to the use of Dex (such as allergic reactions and atrioventricular conduction block).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of perioperative liver dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of perioperative liver dysfunction;Inflammatory factor levels;Liver injury marker levels;Postoperative complications; | — |
Countries
China
Contacts
Public ContactYali Yasen
The First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed