Essential Tremor, Parkinson Disease, neuronal intranuclear inclusion disease
Conditions
Interventions
TAPES treatment:Using a device shaped like a therapeutic wristband and a wrist strap, electrodes on the wrist strap alternately deliver electrical stimulation to the median and radial nerves at the wr
Sham stimulation :Using a wristband and a bracelet with the same appearance, the interior of the wristband was damaged and could not generate effective electrical stimulation. Similarly, the current i
Sponsors
Zhongshan Hospital Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged >=18 years, with no gender preference; 2. Diagnosed with essential tremor, Parkinson's disease, NIID, or peripheral neuropathy accompanied by tremor; 3. At least one item in the TETRAS upper limb score is >=2 (for essential tremor, NIID, or peripheral neuropathic tremor), or at least one item in the UPDRS upper limb tremor score is >=2 (for Parkinson's disease); 4. Voluntarily participate in clinical trials and be able to sign the informed consent form; 5.Able to complete follow-up and evaluation questionnaires.
Exclusion criteria
Exclusion criteria: 1. History of implanted electronic medical devices, such as pacemakers, defibrillators, or deep brain stimulators; 2. Previous thalamotomy for the treatment of tremor, including stereotactic thalamotomy, gamma knife radiosurgery thalamotomy, and focused ultrasound thalamotomy; 3. Previous diagnosis or suspected diagnosis of epilepsy; 4. Pregnant or lactating women; 5. Skin swelling, infection, inflammation, or skin rash, open wound, or skin cancer at the stimulation site; 6. Peripheral neuropathy affecting the examination of the target upper limb; 7. Alcohol abuse; 8. Target upper limb tremor caused by causes other than essential tremor, Parkinson's disease, neuronal intranuclear inclusion disease, or peripheral neuropathy; 9. Use of antidepressants within 3 months before enrollment; 10. Botulinum toxin injection for hand tremor within 6 months before enrollment; 11. Consumption of alcohol or caffeine within 12 hours before enrollment; 12. Other reasons that led the investigator to consider the patient unsuitable for participation in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tremor amplitude; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tremor Power;The Essential Tremor Rating Assessment Scale score for upper extremities;UPDRSIII tremor score(M20,M21);Clinical Global Impressions Scale of Improvement; | — |
Countries
China
Contacts
Public ContactWang Qin
Zhongshan hospital Fudan University
Outcome results
None listed