A Study on Clinical Subtypes of Geriatric Depression and Risk Prediction of Cognitive Impairment Based on Sleep EEG Features

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600123268

Enrollment

Unknown

Registered

2026-04-23

Start date

2026-05-01

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Late-Life Depression

Interventions

Modified electroconvulsive therapy (MECT) group:None

Transcranial temporal interference stimulation (TIS) group:None

Control group:None

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 60 years; 2. Meets the diagnostic criteria for depressive disorder according to the DSM-5; 3. Able to cooperate in completing whole-night sleep EEG (PSG/EEG) monitoring and associated assessments; 4. Possesses the capacity to provide informed consent and voluntarily signs the informed consent form; 5. Baseline cognitive assessment does not meet the diagnostic criteria for dementia; 6. Able to cooperate in completing MRI examination; 7. Agrees to complete follow-up as required by the study protocol.

Exclusion criteria

Exclusion criteria: 1. Clinically diagnosed with dementia (including Alzheimer’s disease, vascular dementia, dementia with Lewy bodies, etc.); 2. Diagnosed with mild cognitive impairment without depressive symptoms; 3. Imaging findings indicating significant brain atrophy or white matter lesions (Fazekas grade >= 2); 4. Definite history of cerebrovascular disease or meeting diagnostic criteria for vascular cognitive impairment; 5. Comorbid poorly controlled severe physical illness; 6. Comorbid severe neurological disorder (e.g., Parkinson’s disease, epilepsy, multiple sclerosis, etc.); 7. Recent use of medications that significantly affect electroencephalographic activity; 8. Comorbid severe primary sleep disorder (e.g., severe obstructive sleep apnea syndrome); 9. Severe hearing, visual, or communication impairments that preclude completion of assessments.

Design outcomes

Primary

Measure	Time frame
Sleep monitoring;	—

Secondary

Measure	Time frame
Mini-Mental State Examination, MMSE;Hamilton Depression Rating Scale, HAMD;Hamilton Anxiety Rating Scale, HAMA;Montreal Cognitive Assessment, MoCA;	—

Countries

China

Contacts

Public ContactXiaoming Kong

Hefei Fourth People’s Hospital

kxm186@126.com+86 551 6557 6893

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026