Acute kidney injury
Conditions
Interventions
C group:For Group C, propofol 1 mg/kg was administered slowly intravenously for induction of anesthesia, and propofol was infused continuously via intravenous pump for maintenance of anesthesia at a r
R1 group:For Group R1, remimazolam 0.2 mg/kg was administered slowly intravenously for induction of anesthesia, and propofol was infused continuously via intravenous pump for maintenance of anesthesia
R2 group:For Group R2, propofol 1 mg/kg was administered slowly intravenously for induction of anesthesia, and remimazolam was infused continuously via intravenous infusion pump for maintenance of ane
R3 group:For Group R3, remimazolam 0.2 mg/kg was administered slowly intravenously for induction of anesthesia, and remimazolam was infused continuously via intravenous infusion pump for maintenance o
Sponsors
The Third Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective laparoscopic radical nephrectomy (LRN) under general anesthesia in our hospital; 2. Aged 45 to 80 years; 3. ASA physical status classification ?–?; 4. Patients with normal preoperative cardiac, hepatic and renal function; 5. Written informed consent obtained from patients or their legal representatives.
Exclusion criteria
Exclusion criteria: 1. Patients who have used nephrotoxic drugs within 3 months preoperatively; 2. Patients with a history of secondary renal surgery; 3. Patients with a history of severe infection, shock, or other conditions requiring emergency resuscitation preoperatively; 4. Patients who develop major complications such as severe cardiovascular and cerebrovascular accidents or massive bleeding intraoperatively and postoperatively; 5. Patients allergic to the anesthetic agents used in the study (including remimazolam)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral Perfusion Index;Serum Creatinine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glomerular Filtration Rate;Cystatin C;ß2-microglobulin;C-reactive protein;Heart rate;Mean arterial pressure;Blood oxygen saturation;Central venous oxygen saturation;Arterial blood lactate;Cardiac output;Stroke volume variability;Operative time;Intravenous fluid volume;Blood loss;Urinary output;Temperature; | — |
Countries
China
Contacts
Public ContactLiu Yongzhe
The Third Medical Center, Chinese People's Liberation Army General Hospital
Outcome results
None listed