Aging
Conditions
Interventions
Control group:Subjects sat in a negative pressure chamber for one hour twice a week, with the negative pressure set at normal atmospheric pressure: 90 kPa. The total treatment course included 8 interv
Experimental group:Subjects sat in a negative pressure chamber for one hour twice a week, with the negative pressure set at normal atmospheric pressure: 50 kPa. The total treatment course included 8 i
Sponsors
Sun Yat-sen University Affiliated Stomatological Hospital
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Subjects >=40 years old, male or female; 2. No cognitive impairment; 3. The subjects have no severe hypertension, cardiovascular and cerebrovascular diseases, ear diseases or hearing disorders, and no large wounds or exposed wounds; 4. 18.5kg/m^2 =50kg, female weight >=45kg; 5. No treatment related to chemoradiation, immunosuppressive drugs or flavonoids were used; 6. The subjects fully understand the purpose and requirements of the trial, voluntarily participate in the clinical trial and sign a written informed consent, and are willing to complete the entire trial process according to the requirements of the trial.
Exclusion criteria
Exclusion criteria: 1. People with obvious mental disorders; 2. Claustrophobic subjects; 3. High myopia (>=1000 degrees), severe glaucoma, cataract, severe ear disease or hearing impairment; 4. Serious heart, lung, liver, kidney dysfunction; 5. Patients with a history of epilepsy (excluding febrile convulsions in children); 6. Pregnant and lactating women; 7. Subjects that the researcher considers inappropriate to participate in this experiment; 8. Other subjects who are not suitable for negative pressure therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete Blood Count Type;Liver and kidney function tests;Coagulation function;Blood lipid level;Number of senescent cells in the blood;Serum inflammatory factor levels;Age-related genes and proteins; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mitochondrial function;Bodily functions;Skin aging;Metabolic and immune functions; | — |
Countries
China
Contacts
Public ContactXueli Mao
Sun Yat-sen University Affiliated Stomatological Hospital
Outcome results
None listed