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Morphometric Analysis of Meibomian Glands and Levator Palpebrae Superioris in Thyroid Eye Disease with Upper Eyelid Retraction: An AI-Driven Quantitative Approach

Morphometric Analysis of Meibomian Glands and Levator Palpebrae Superioris in Thyroid Eye Disease with Upper Eyelid Retraction: An AI-Driven Quantitative Approach

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600123246
Enrollment
Unknown
Registered
2026-04-23
Start date
2026-04-25
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid eye disease upper eyelid retraction

Interventions

NA:LPSC morphological characteristics (thickness and area of the anterior and middle parts of the muscle)

Sponsors

Eye Hospital, Wenzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 69 Years

Inclusion criteria

Inclusion criteria: 1. Diagnosis of TED according to the Bartley criteria. 2. Aged >= 18 years and = 1 mm between the affected and contralateral eyes.

Exclusion criteria

Exclusion criteria: 1. Concurrent dry eye due to other causes, such as Sjögren's syndrome; 2. Use of medications affecting tear film or meibomian gland function within the past 3 months; 3. Systemic or topical use of glucocorticoids, immunosuppressants, or biologics within the past 3 months; 4. Contact lens wear; 5. Local injection of botulinum toxin into the eyelids within the past 6 months; 6. Poor quality of meibomian gland images, ocular surface images, or CT images that precludes analysis.

Design outcomes

Primary

MeasureTime frame
Parameters of the upper eyelid meibomian glands measured by AI (such as contrast value, density);

Secondary

MeasureTime frame
Tear River Height (TMH);Non-Invasive Tear Break-Up Time, NBUT;

Countries

China

Contacts

Public ContactFang Wei

Eye Hospital, Wenzhou Medical University

andyfang000@163.com+86 571 86072073

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026