Periodontitis
Conditions
Interventions
Experimental group:After completing the basic periodontal treatment, the subjects sat in a hypobaric pressure chamber for one hour every three days, with a negative pressure intensity of 50kPa. The to
Control group:The subjects complete the periodontal basic treatment.
Sponsors
Stomatological Hospital Affiliated to Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 68 Years
Inclusion criteria
Inclusion criteria: 1. In each quadrant, at least 3 teeth have a probing depth (PD) of >= 5 mm and a clinical attachment loss (CAL) of >= 3 mm, the proportion of (+) bleeding on probing (BOP) sites in the entire mouth is > 40%, and there are more than 15 remaining teeth in the mouth (excluding the third molars); 2. The age range is 18 to 68 years old; 3. All study subjects are in good overall health, have no recent medication history, no systemic diseases, and no allergy history; 4. Within 3 months, no antibiotics or non-steroidal anti-inflammatory drugs have been taken; 5. There are no obvious oral mucosal diseases, no ongoing oral diseases in treatment, and patients who have completed periodontal basic treatment and are in maintenance period; 6. The patients fully understand the purpose and requirements of this trial, voluntarily participate in the clinical trial and sign a written informed consent form, and are willing to complete all the trial procedures as required.
Exclusion criteria
Exclusion criteria: 1. Those with severe or unstable cardiovascular, respiratory, liver, kidney, hematological, endocrine and central nervous system diseases; 2. Those who had severe alcohol or drug dependence within the previous year (excluding caffeine or nicotine), or those who consumed alcohol at a daily intake of 5 units or more (1 unit = 360 mL beer or 45 mL white wine or 120 mL wine); 3. Those who have doubts about the treatment plan or have obvious mental and psychological disorders; 4. Those with irregular and need to work night shifts; 5. Those who had an infection history within the previous month, needed hospitalization and/or antibiotic treatment, or are currently using systemic hormones (glucocorticoids), immunosuppressants or cytotoxic treatments; 6. Pregnant and lactating women; 7. Those with ear diseases such as otitis media, perforated eardrum, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Periodontal probing examination;Conical Beam CT of the Entire Dentition of the Mouth;Complete Blood Count;Lymphocyte senescence detection;Serum inflammatory factor levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| Coagulation function;Blood lipid level; | — |
Countries
China
Contacts
Public ContactXueli Mao
Stomatological Hospital Affiliated to Sun Yat-sen University
Outcome results
None listed